Information Technology (IT) is making its way into buildings, generating real-time data streams that could potentially inform spatial, social, and operational adaptations to meet people's needs. This projects aims at developing the "brain" of intelligent buildings, which are capable of sensing human behavior (through sensors, IT systems, and IoT devices), predicting the implications of alternative resource allocation strategies (such as spaces, people, and equipment), and informing the real-time operations of complex facilities (such as hospitals) to improve space utilization, operational efficiency, and people's experience.